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Acute SIRT2 inhibition affects mTORC1-dependent protein synthesis in NRCMs Since our in vitro results demonstrate that SIRT2 is a negative regulator of protein synthesis, and Sirt2 -KO mice hearts exhibit upregulated protein synthesis concomitant with increased mTORC1 activity, we wanted to investigate whether acute SIRT2 manipulation has a similar effect in cardiac cells

For example, chondrocytes isolated from OA cartilage displayed significant senescence levels, and ABT263 treatment reduced the expression of inflammatory cytokines and promoted cartilage matrix aggregation in OA chondrocytes (Yang et al., 2020)

If you notice side effects after beginning with a low dosage, increasing your dosage is not recommended

Some advanced research protocols do explore concurrent use